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Il est préférable de laisser s'écouler un intervalle d'au moins 6 heures entre l'application du gel et le bain ou la douche.If a CNS depressant or benzodiazepine are necessary in a very patient presently on an opioid analgesic: Initiate that has a decreased Original dose of the benzodiazepine or other CNS depressant; titrate depending on clinica